Ethanolamine → HCID 59415982, Verbindung

HRID 2061824Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2061824
[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]3[CH:16]=[N:17][C:18]([NH:30][C:31]([NH:33][CH2:34][CH2:35][CH3:36])=[O:32])=[CH:19][C:20]=3[C:21]3[S:22][CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[N:25]=3)=[CH:12][CH:13]=2)[C:8](=[O:37])[C:7]([C:38](OCC)=[O:39])=[CH:6]1.[CH2:44]([CH2:46][NH2:47])[OH:45]>>[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]3[CH:16]=[N:17][C:18]([NH:30][C:31]([NH:33][CH2:34][CH2:35][CH3:36])=[O:32])=[CH:19][C:20]=3[C:21]3[S:22][CH:23]=[C:24]([C:26]([F:28])([F:27])[F:29])[N:25]=3)=[CH:12][CH:13]=2)[C:8](=[O:37])[C:7]([C:38]([NH:47][CH2:46][CH2:44][OH:45])=[O:39])=[CH:6]1

Komponenten

3

Edukt 2

HCID 700EthanolamineHCID 44540348HCID 44540348, Verbindung

Produkt 1

HCID 59415982HCID 59415982, Verbindung

Reaktionsbedingungen

Temperatur
87.5 °C

Versuchsvorschrift

A suspension of ethyl 1-(2-(dimethylamino)ethyl)-4-oxo-6-(6-(3-propylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate (Example 174, 50 mg, 0.09 mmol) in ethanolamine (0.5 mL) was heated to 85-90° C. for 3 h. The reaction mixture was cooled to room temperature and the precipitate that formed was isolated by filtration and washed with acetonitrile and water then dried overnight under high vacuum.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthe precipitate that formed
  3. customwas isolated by filtration
  4. washwashed with acetonitrile and water
  5. customthen dried overnight under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-19d9f4ea2c8248ee9975e41e9d046221
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08283361B2

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