4-Phenylpiperidine → 1-Piperidinesulfonamide, 4-phenyl-

HRID 2061915Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2061915
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:13](N)([NH2:16])(=[O:15])=[O:14]>O1CCOCC1>[NH2:16][S:13]([N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)(=[O:15])=[O:14]

Komponenten

4

Edukt 2

HCID 698734-PhenylpiperidineHCID 82267Sulfamide

Produkt 1

HCID 119990221-Piperidinesulfonamide, 4-phenyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

4-Phenyl-piperidine (10 g, 62 mmol) was dissolved in dioxane (100 mL). Sulfamide (23.8 g, 248 mmol) was then added and the reaction mixture heated to 100° C. for 14 h. The reaction mixture was then cooled to room temperature, quenched by addition of 1N HCl and then concentrated to remove dioxane. The product was extracted with ethyl acetate (100 mL), dried (Na2SO4), filtered and concentrated to yield the title compound as a light brown solid.

Aufarbeitung

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. customquenched by addition of 1N HCl
  3. concentrationconcentrated
  4. customto remove dioxane
  5. extractionThe product was extracted with ethyl acetate (100 mL)
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d0a30a179f2d44099ca63f03c1ba702d
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08283478B2

Notizen zur Reaktion

Wird geladen…