Ammonia → 3-Benzyl-1,2,4-thiadiazol-5-amine

HRID 2063669

Reaktionsgleichung

Reaktionsgleichung von HRID 2063669
[CH2:1]([C:8]1[N:12]=[C:11](Cl)[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:14]>>[CH2:1]([C:8]1[N:12]=[C:11]([NH2:14])[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 147635213-Benzyl-5-chloro-1,2,4-thiadiazole

Produkt 1

HCID 6055933-Benzyl-1,2,4-thiadiazol-5-amine

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 3-benzyl-5-chloro-[1,2,4]thiadiazole (105 mg, 0.5 mmol) in ammonia (2 N in MeOH, 2 ml) was heated in a pressure tube at 50° C. for 5 h. The solvents were evaporated, the residue diluted with dichloromethane, the white solid (ammonium chloride) was filtered off, the filtrate was concentrated and then purified by silica gel chromatography using dichloromethane/methanol as eluent. The title compound was obtained as a light yellow liquid (40 mg, 41%). MS ISP (m/e): 192.1 (100) [(M+H)+].

Aufarbeitung

  1. customThe solvents were evaporated
  2. additionthe residue diluted with dichloromethane
  3. filtrationthe white solid (ammonium chloride) was filtered off
  4. concentrationthe filtrate was concentrated
  5. custompurified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-627c223dfef649a5a6faf340263f78f3
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288403B2

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