Ethyl vinyl ether → 4-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

HRID 2063718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2063718
[CH:1]([O:3][CH2:4][CH3:5])=[CH2:2].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[NH+]1C=CC=CC=1.[OH:23][CH:24]([CH:32]1[CH2:37][CH2:36][C:35](=[O:38])[CH2:34][CH2:33]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[CH2:1]([O:3][CH:4]([O:23][CH:24]([CH:32]1[CH2:33][CH2:34][C:35](=[O:38])[CH2:36][CH2:37]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:5])[CH3:2]

Komponenten

5

Edukt 3

HCID 8023Ethyl vinyl etherHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 214336324-(1-Hydroxy-2-phenylethyl)cyclohexanone

Produkt 1

HCID 668875294-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Ethyl vinyl ether (998 mg, 1.32 ml, 13.8 mmol) and pyridinium tosylate (44 mg, 0.17 mmol) were added to a solution of 4-(1-hydroxy-2-phenylethyl)cyclohexanone (2.52 g, 11.5 mmol) in anhydrous methylene chloride (50 ml) and the mixture was stirred at room temperature overnight. Methylene chloride (20 ml) was added to the mixture and the mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

Aufarbeitung

  1. washthe mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each)
  2. dry with materialThe combined organic phases were dried with sodium sulfate
  3. concentrationconcentrated i

Quellen und Nachweise

ORD-Eintrag
ord-8c79fd8dea9c466884db519ac85f7bf5
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288406B2

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