HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Selectfluor → 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Selectfluor | HCID 2724933 | — |
| Edukt | 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174793 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one | HCID 86618134 | — |
Reaktionsschritte
A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745646B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-1f2b2ae8e5f1496aafb24688b567536b |
| Quellennotiz | uspto-grants-2010_06 |