Imidazo(1,2-a)pyridine-3-carboxylic acid → (1S,3S,5S)-3-{[(Imidazo[1,2-a]pyridine-3-carbonyl)-amino]-methyl}-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH2:15])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:16]1[CH:17]=[C:18]([C:25](O)=[O:26])[N:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=12>>[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH:15][C:25]([C:18]2[N:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]3=[N:16][CH:17]=2)=[O:26])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with imidazo[1,2-a]pyridine-3-carboxylic acid. LC-MS (acidic): tR=0.74 min; [M+H]+=357.1.
Quellen und Nachweise
- ORD-Eintrag