2-Chloroaniline → 4-(2-Chlorophenylamino)-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one
Reaktionsgleichung
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]1[C:19]2[C:14](=[C:15]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[O:13][C:12](=[O:28])[CH:11]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10]1[C:19]2[C:14](=[C:15]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[O:13][C:12](=[O:28])[CH:11]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2-chloroaniline and 4-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one following the procedure outlined in Example 16. 1H NMR (400 MHz, DMSO-d6): δ 9.28 (s, 1H), 7.93 (d, 1H), 7.66 (d, 1H), 7.51-7.40 (m, 3H), 7.15 (d, 1H), 4.83 (m, 1H), 4.50 (s, 1H), 3.90 (s, 3H), 1.90-1.45 (m, 8H); MS (ESI): 385.9.
Quellen und Nachweise
- ORD-Eintrag
- ord-21e97f082af14a2ab98ae31140d9d558
- Quelldatensatz
- uspto-grants-2010_06