2-Methylimidazo(2,1-b)(1,3)thiazole-5-carboxylic acid → 2-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
Reaktionsgleichung
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH3:24][C:25]1[S:29][C:28]2=[N:30][CH:31]=[C:32]([C:33](O)=[O:34])[N:27]2[CH:26]=1>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:33]([C:32]3[N:27]4[C:28]([S:29][C:25]([CH3:24])=[CH:26]4)=[N:30][CH:31]=3)=[O:34])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 2-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid. LC-MS (basic): tR=0.78 min; [M+H]+=497.1.