3-Methylimidazo[2,1-b]thiazole-2-carboxylic acid → 3-methyl-imidazo[2,1-b]thiazole-2-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

HRID 2064871

Reaktionsgleichung

Reaktionsgleichung von HRID 2064871
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH3:24][C:25]1[N:26]2[CH:35]=[CH:34][N:33]=[C:27]2[S:28][C:29]=1[C:30](O)=[O:31]>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:30]([C:29]3[S:28][C:27]4=[N:33][CH:34]=[CH:35][N:26]4[C:25]=3[CH3:24])=[O:31])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Komponenten

3

Edukt 2

HCID 569657253-Methylimidazo[2,1-b]thiazole-2-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Produkt 1

HCID 866536623-methyl-imidazo[2,1-b]thiazole-2-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

Versuchsvorschrift

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 3-methyl-imidazo[2,1-b]thiazole-2-carboxylic acid. LC-MS (basic): tR=0.74 min; [M+H]+=497.2.

Quellen und Nachweise

ORD-Eintrag
ord-a76f32b4f629425f94c8ac07345edf29
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288435B2

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