3-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid → 3-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

HRID 2064881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2064881
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH3:24][C:25]1[C:29]([C:30](O)=[O:31])=[C:28]([C:33]([F:36])([F:35])[F:34])[O:27][N:26]=1>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:30]([C:29]3[C:25]([CH3:24])=[N:26][O:27][C:28]=3[C:33]([F:36])([F:34])[F:35])=[O:31])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Komponenten

3

Edukt 2

HCID 27756453-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Produkt 1

HCID 866536723-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

Versuchsvorschrift

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 3-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid. LC-MS (basic): tR=0.85 min; [M+H]+=510.2.

Quellen und Nachweise

ORD-Eintrag
ord-aaabb6576e624366b565e111966b39f4
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288435B2

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