5-(4-Methoxyphenyl)-1,3-oxazole-4-carboxylic acid → 5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide
Reaktionsgleichung
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([NH2:12])[CH:9]=[N:8]1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[O:27][CH:26]=[N:25][C:24]=2[C:28](O)=[O:29])=[CH:19][CH:18]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([NH:12][C:28]([C:24]2[N:25]=[CH:26][O:27][C:23]=2[C:20]2[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=2)=[O:29])[CH:9]=[N:8]1Komponenten
3
Versuchsvorschrift
Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-4-ylamine and 5-(4-methoxy-phenyl)-oxazole-4-carboxylic acid. LC-MS-conditions 05b: tR=1.12 min; [M+H]+=405.20.
Quellen und Nachweise
- ORD-Eintrag
- ord-6e5f84925dc04526984f534bb2091b83
- Quelldatensatz
- uspto-grants-2012_10
- DOI