Potassium Hydroxide → HCID 178517804, Verbindung

HRID 2065504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2065504
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1.[OH-:13].[K+]>CO>[Cl:1][C:2]1[N:7]=[C:6]([OH:13])[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 592990517-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine

Produkt 1

HCID 178517804HCID 178517804, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

7-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine (181 mg, 0.91 mmol) was dissolved in MeOH (4 ml). 2N KOH (8 ml) was added and the mixture was stirred at reflux for 2 hours. The solvents were removed by a rotavap. The residue was added 4N HCl in dioxane and stirred for an hour before it was concentrated. Water was added and the mixture was extracted with DCM to give 7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidin-5-ol (35 mg) as a solid. [M+H] calc'd for C5H3ClN4O, 171; found, 171.

Aufarbeitung

  1. temperatureat reflux for 2 hours
  2. customThe solvents were removed by a rotavap
  3. additionThe residue was added 4N HCl in dioxane
  4. stirringstirred for an hour before it
  5. concentrationwas concentrated
  6. additionWater was added
  7. extractionthe mixture was extracted with DCM

Quellen und Nachweise

ORD-Eintrag
ord-b9d5c6fda8574a23b5a5ab973f34ae34
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288536B2

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