1H-Pyrazol-3-amine, 5-methyl- → (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

HRID 2065506

Reaktionsgleichung

Reaktionsgleichung von HRID 2065506
[Br:1][C:2]1[N:3]=[C:4](Br)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[CH3:12][C:13]1[NH:17][N:16]=[C:15]([NH2:18])[CH:14]=1>CCO>[Br:1][C:2]1[N:3]=[C:4]([NH:18][C:15]2[CH:14]=[C:13]([CH3:12])[NH:17][N:16]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1

Komponenten

4

Edukt 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Produkt 1

HCID 86237295(6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(5-methyl-1H-pyrazol-3-yl)-amineAusbeute 32,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

Example 8 was then prepared as follows. 6,8-Dibromoimidazo[1,2-a]pyrazine (278 mg, 1 mmol) and 5-methyl-1H-pyrazol-3-amine (196 mg, 2 mmol) was suspended in EtOH (2 ml). The mixture was heated with microwave at 120° C. for four hours. The mixture was then purified with HPLC to give (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(5-methyl-1H-pyrazol-3-yl)-amine as a solid (96 mg). 1H NMR (400 MHz, DMSO) δ 8.29 (s, 1H) 7.98 (s, 1H) 7.70 (s, 1H) 6.48 (s, 1H) 2.27 (s, 3H). [M+H] calc'd for C10H9BrN6, 293; found, 293.

Aufarbeitung

  1. customExample 8 was then prepared
  2. customThe mixture was then purified with HPLC

Quellen und Nachweise

ORD-Eintrag
ord-68e7368af99842b9b528da021d8cb847
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288536B2

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