Hydrochloric Acid → 2-((S)-1-Carboxy-2-phenyl-ethylamino)-6-chloro-quinoline-3-carboxylic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 2,6-dichloroquinoline-3-carboxylic acid (243 mg, 1 mmol), L-phenylalanine (330 mg, 2 mmol) and potassium carbonate (415 mg, 3 mmol) in water (3 mL) is stirred for 24 h at 135° C. in closed reaction vial. After cooling, the reaction mixture is acidified by addition of 2N HCl, and the precipitated solid is collected on filter, washed with water and recrystallized from DMF-water to give the title compound (211 mg, 57%) as yellow needles.

Herkunft & Nachweise