2-Phenylglycine → 2-[(Carboxy-phenyl-methyl)-amino]-6-chloro-quinoline-3-carboxylic acid

HRID 2065594

Reaktionsgleichung

Reaktionsgleichung von HRID 2065594
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH2:26])[C:23]([OH:25])=[O:24])=[CH:18][CH:17]=1>>[C:23]([CH:22]([NH:26][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[C:19]1[CH:18]=[CH:17][CH:16]=[CH:21][CH:20]=1)([OH:25])=[O:24]

Komponenten

3

Edukt 2

HCID 38662-PhenylglycineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Produkt 1

HCID 452568752-[(Carboxy-phenyl-methyl)-amino]-6-chloro-quinoline-3-carboxylic acidAusbeute 33 %

Versuchsvorschrift

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-phenylglycine to provide the title compound in 33% yield as yellow needles (recrystallization from DMF/water).

Quellen und Nachweise

ORD-Eintrag
ord-4c4ba31ec50b4fb9a7bc0ee05d0fc958
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288549B2

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