3-Tyrosine, DL- → 2-[1-Carboxy-2-(3-hydroxy-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid

HRID 2065643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2065643
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[OH:16][C:17]1[CH:18]=[C:19]([CH:26]=[CH:27][CH:28]=1)[CH2:20][CH:21]([C:23]([OH:25])=[O:24])[NH2:22]>>[C:23]([CH:21]([NH:22][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:20][C:19]1[CH:26]=[CH:27][CH:28]=[C:17]([OH:16])[CH:18]=1)([OH:25])=[O:24]

Komponenten

3

Edukt 2

HCID 130523-Tyrosine, DL-HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Produkt 1

HCID 452555822-[1-Carboxy-2-(3-hydroxy-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid

Versuchsvorschrift

In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 3-hydroxy-DL-phenylalanine and crude product is separated by flash chromatography on SiO2 to provide the title compound in low yield.

Aufarbeitung

  1. customis separated by flash chromatography on SiO2

Quellen und Nachweise

ORD-Eintrag
ord-6d5e19db7e3c4509a4c651291bf9647b
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288549B2

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