Pyrroline → 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone
Reaktionsgleichung
[N+:1]([CH2:3][C:4]([O:6]C)=O)#[C-:2].[NH:8]1[CH:12]=[CH:11][CH2:10][CH2:9]1>>[N+:1]([CH2:3][C:4]([N:8]1[CH2:12][CH:11]=[CH:10][CH2:9]1)=[O:6])#[C-:2]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
Prepared in accordance with Method B with methyl isocyanoacetate (1.00 g, 10.10 mmol) and dihydro-1H-pyrrole (1.01 mL, 15.15 mmol). The reaction mixture was stirred 5 h at 50° C. and concentrated. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed with 10% aqueous citric acid (2×25 mL), dried over MgSO4, filtered and evaporated. 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone SLA 07178 was obtained (1.0 g, 73% yield) as a yellow solid.
Aufarbeitung
- concentrationconcentrated
- dissolutionThe residue was dissolved in dichloromethane (50 mL)
- washthe organic layer was washed with 10% aqueous citric acid (2×25 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-c727136b7f9347838d7449510bdca911
- Quelldatensatz
- uspto-grants-2012_10
- Patentnummer
- US08288556B2
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