Ethyl isocyanate → HCID 58333511, Verbindung

HRID 2066845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2066845
[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([O:13][N:14]=[C:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[C:25]([F:27])[C:24]([CH2:28][NH2:29])=[CH:23][C:22]=3[F:30])[CH2:17][CH2:16]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH2:38]([N:40]=[C:41]=[O:42])[CH3:39]>C(Cl)Cl>[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([O:13][N:14]=[C:15]2[CH2:16][CH2:17][N:18]([C:21]3[CH:26]=[C:25]([F:27])[C:24]([CH2:28][NH:29][C:41]([NH:40][CH2:38][CH3:39])=[O:42])=[CH:23][C:22]=3[F:30])[CH2:19][CH2:20]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 86655007HCID 86655007, Verbindung

Produkt 1

HCID 58333511HCID 58333511, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 16a (23 mg) and triethylamine (0.1 mL) in 1 mL of DCM was added a drop of ethyl isocyanate (excess) and the reaction mixture was stirred for 30 minutes at room temperature. The mixture was then quenched with water and extracted with DCM to give 33 mg of crude product which was purified on preparative HPLC to give 16-1: LC-MS 496.2 (MH+).

Aufarbeitung

  1. customThe mixture was then quenched with water
  2. extractionextracted with DCM

Quellen und Nachweise

ORD-Eintrag
ord-9524d7c84d23434a91f7a535c3f5cd4a
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293729B2

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