Trimethylsilylacetylene → HCID 68421800, Verbindung

HRID 2067219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067219
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1C)=[O:18].BrC1C=CC(OC)=C([C:39](C2C=CC(NC3C=CC(F)=CC=3F)=CC=2Cl)=[O:40])C=1.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[O:40][CH3:39])=[O:18]

Komponenten

4

Edukt 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552, VerbindungHCID 68417297(5-Bromo-2-methoxy-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

Produkt 1

HCID 68421800HCID 68421800, Verbindung

Versuchsvorschrift

The reaction was carried out similarly as described in the preparation of compound 406, using compound 425 (0.99 mmol) and ethynyltrimethylsilane (0.99 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 10:90 as the eluent to afford the title compound as light orange syrup.

Aufarbeitung

  1. customThe crude product was purified by continuous gradient flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2983d175c9a740c6ab988f3f97eda0f4
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293772B2

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