HCID 11541444, Verbindung → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[1-(2-hydroxy-ethyl)-1H-[1,2,3]triazol-4-yl]-2-methoxy-phenyl}-methanone
Reaktionsgleichung
ClC1C=C(NC2C=CC(F)=CC=2F)C=CC=1C(C1C=C(C2N=NN(CCOC3CCCCO3)C=2)C=CC=1C)=O.[Cl:40][C:41]1[CH:46]=[C:45]([NH:47][C:48]2[CH:53]=[CH:52][C:51]([F:54])=[CH:50][C:49]=2[F:55])[CH:44]=[CH:43][C:42]=1[C:56]([C:58]1[CH:63]=[C:62]([C:64]2[N:65]=[N:66][N:67]([CH2:69][CH2:70][O:71]C3CCCCO3)[CH:68]=2)[CH:61]=[CH:60][C:59]=1[O:78][CH3:79])=[O:57]>>[Cl:40][C:41]1[CH:46]=[C:45]([NH:47][C:48]2[CH:53]=[CH:52][C:51]([F:54])=[CH:50][C:49]=2[F:55])[CH:44]=[CH:43][C:42]=1[C:56]([C:58]1[CH:63]=[C:62]([C:64]2[N:65]=[N:66][N:67]([CH2:69][CH2:70][OH:71])[CH:68]=2)[CH:61]=[CH:60][C:59]=1[O:78][CH3:79])=[O:57]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The reaction was carried out similarly as described in the preparation of compound 101, using compound 119 (0.11 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 20:80 to 100:0 as the eluent to afford the title compound as yellow foam.