Trimethylsilylacetylene → HCID 68418431, Verbindung

HRID 2067226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067226
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(I)C=CC=1C)=O.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

Komponenten

4

Edukt 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552, VerbindungHCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

Produkt 1

HCID 68418431HCID 68418431, Verbindung

Versuchsvorschrift

The reaction was carried out similarly as described in the preparation of compound 406, using compound 430 (7.17 mmol) and ethynyltrimethylsilane (7.17 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:8 as the eluent to afford the title compound as yellow solid.

Aufarbeitung

  1. customThe crude product was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-16cd4c58670c4f8ba427ad94984154f5
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293772B2

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