HCID 11577394, Verbindung → HCID 11633801, Verbindung

HRID 2067229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067229
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][OH:32])[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:33])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(C2N=NN(CCOC3CCCCO3)C=2)C=CC=1C)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][OH:32])[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:33])=[O:18]

Komponenten

3

Edukt 2

HCID 11577394HCID 11577394, VerbindungHCID 11612479HCID 11612479, Verbindung

Produkt 1

HCID 11633801HCID 11633801, Verbindung

Versuchsvorschrift

The reaction was carried out similarly as described in the preparation of compound 102, using compound 121 (1.63 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 100:0 as the eluent to afford the title compound as yellow syrup.

Aufarbeitung

  1. customThe crude product was purified by continuous gradient flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-060a10055dab4aa9a2192df2b6f74f24
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293772B2

Notizen zur Reaktion

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