4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane → HCID 11685044, Verbindung

HRID 2067230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067230
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][O:32][CH:33]3[CH2:38]CC[CH2:35][O:34]3)[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:39])=[O:18].Cl[C:41]1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(C#C)C=CC=1C)=O.N(CC1COC(C)(C)O1)=[N+]=[N-]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH:31]3[CH2:35][O:34][C:33]([CH3:38])([CH3:41])[O:32]3)[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:39])=[O:18]

Komponenten

4

Edukt 3

HCID 115356024-(Azidomethyl)-2,2-dimethyl-1,3-dioxolaneHCID 11706669[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanoneHCID 86605527HCID 86605527, Verbindung

Produkt 1

HCID 11685044HCID 11685044, Verbindung

Versuchsvorschrift

The reaction was carried out similarly as described in the preparation of compound 101, using compound 432 (2.75 mmol) and compound 410 (2.75 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 20:80 to 65:35 as the eluent to afford the title compound as foam.

Aufarbeitung

  1. customThe crude product was purified by continuous gradient flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-892c0de2bbf949ca978c97113cdcaf4e
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293772B2

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