1-Bromo-2-propanol → 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

HRID 2067764

Reaktionsgleichung

Reaktionsgleichung von HRID 2067764
[OH:1][C@H:2]([CH2:26]O)[CH2:3][N:4]1[C:9](=[O:10])[C:8]2[C:11]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([I:24])=[CH:20][C:19]=3[F:25])=[CH:12][C:13](=[O:16])[N:14]([CH3:15])[C:7]=2[N:6]=[CH:5]1.NC1C=CC(NC2C3C(=O)NC=NC=3N(C)C(=O)C=2)=C(F)C=1.BrCC(O)C>>[F:25][C:19]1[CH:20]=[C:21]([I:24])[CH:22]=[CH:23][C:18]=1[NH:17][C:11]1[C:8]2[C:9](=[O:10])[N:4]([CH2:3][CH:2]([OH:1])[CH3:26])[CH:5]=[N:6][C:7]=2[N:14]([CH3:15])[C:13](=[O:16])[CH:12]=1

Komponenten

4

Edukt 3

HCID 297401-Bromo-2-propanolHCID 24965731(S)-3-(2,3-Dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dioneHCID 1357416545-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Produkt 1

HCID 249678835-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Versuchsvorschrift

The title compound was prepared following the same procedure for the synthesis of Compound 5G using compound 5F and 1-bromopropan-2-ol as starting material. 1H NMR (400 MHz, CDCl3) δ 8.17 (s, 1 H) 7.52 (m, 2 H) 7.24 (t, J=8.84 Hz, 1H) 5.81 (s, 1 H) 4.39 (m, 1 H) 4.25 (m, 1 H) 3.57 (m, 4 H), 1.35 (d, J=6.32 Hz, 3 H). [M+H] calc'd for C17H16FIN4O3, 471; found, 471.

Quellen und Nachweise

ORD-Eintrag
ord-eb4a08e5cb914662b31751eda8498894
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293901B2

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