Butaclamol → Dopamine

HRID 2068454

Reaktionsgleichung

Reaktionsgleichung von HRID 2068454
C[N:2]1[CH2:12][C@H:11](C2C=CC=CC=2)[C:10]2[CH:9]=[C:8]([OH:19])[C:7](Cl)=[CH:6][C:5]=2CC1.CC([C@]1([OH:47])C[C@H]2N(C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:2][CH2:12][CH2:11][C:10]1[CH:5]=[CH:6][C:7]([OH:47])=[C:8]([OH:19])[CH:9]=1

Komponenten

3

Edukt 2

HCID 37461ButaclamolHCID 3036864R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol

Produkt 1

HCID 681Dopamine

Versuchsvorschrift

HEK cells were transfected with DNA encoding D1-NLS-GFP (2 micrograms), and D1-WT (6 micrograms) for 48 hours. These cells were treated 6 hrs after transfection with SCH-23390 (10 micromolar), or (+)butaclamol (10 micromolar). The medium containing antagonist was changed at 6, 22, 30 and 42 hours after transfection. Control cells received no antagonist treatment.

Aufarbeitung

  1. additionThe medium containing antagonist
  2. customwas changed at 6, 22, 30 and 42 hours

Quellen und Nachweise

ORD-Eintrag
ord-5aa46aa9df904691aae8b1a8f824f6dc
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08298777B2

Verknüpfte Notizen

Wird geladen…