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Sodium Hydroxide → [1-(6-Chloropyridazin-3-yl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]acetic acid

HRID 2068482
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2068482
[OH-].[Na+].C[O:4][C:5](=[O:26])[CH2:6][C:7]1[C:8]([CH3:25])=[N:9][N:10]([C:18]2[N:19]=[N:20][C:21]([Cl:24])=[CH:22][CH:23]=2)[C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[Cl:24][C:21]1[N:20]=[N:19][C:18]([N:10]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:7]([CH2:6][C:5]([OH:26])=[O:4])[C:8]([CH3:25])=[N:9]2)=[CH:23][CH:22]=1
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Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 131730043methyl[1-(6-chloropyridazin-3-yl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]acetate

Produkt 1

HCID 86642722[1-(6-Chloropyridazin-3-yl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

0.058 g (1.444 mmol) of 2-molar aqueous sodium hydroxide solution was added to 0.099 g (0.289 mmol) of methyl[1-(6-chloropyridazin-3-yl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]acetate in 5.00 ml of methanol, and the mixture was stirred at 20° C. for 1 h. The methanol was removed under reduced pressure and the residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane. The aqueous phase was extracted with 15 ml of dichloromethane, acidified with concentrated hydrochloric acid (pH=3) and extracted three times with in each case 15 ml of dichloromethane. Drying of the combined organic phases and removal of the solvent under reduced pressure gave 0.052 g (54.7% of theory) of a brown wax-like solid.

Aufarbeitung

  1. customThe methanol was removed under reduced pressure
  2. additionthe residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane
  3. extractionThe aqueous phase was extracted with 15 ml of dichloromethane
  4. extractionextracted three times with in each case 15 ml of dichloromethane
  5. customDrying of the combined organic phases and removal of the solvent under reduced pressure
  6. customgave 0.052 g (54.7% of theory) of a brown wax-like solid

Quellen und Nachweise

ORD-Eintrag
ord-d36ab2cede2943ae9d71b6046240b9b9
Quelldatensatz
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08298994B2

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