Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid

HRID 2068635

Reaktionsgleichung

Reaktionsgleichung von HRID 2068635
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>>[O:13]1[CH:14]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[N:11]=[CH:12]1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 581102445-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester

Produkt 1

HCID 581102215-Oxazol-4-yl-thiophene-3-carboxylic acidAusbeute 100,2 %

Versuchsvorschrift

5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).

Aufarbeitung

  1. customThe mixture was quenched with HCl (1 N, 0.35 mL)
  2. concentrationconcentrated
  3. customazeotroping twice with methanol

Quellen und Nachweise

ORD-Eintrag
ord-a9e15b923af248999376c9b186edc511
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299063B2

Verknüpfte Notizen

Wird geladen…