Disodium acetylide → 9-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)nonanoic acid

HRID 20687

Reaktionsgleichung

Reaktionsgleichung von HRID 20687
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12]CC)=[O:11].[Cl:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([Cl:37])[C:21]=1[NH:22][C:23]1[C:32]2[C:27](=[C:28]([OH:35])[C:29]([O:33][CH3:34])=[CH:30][CH:31]=2)[O:26][C:25](=[O:36])[CH:24]=1>>[Cl:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([Cl:37])[C:21]=1[NH:22][C:23]1[C:32]2[C:27](=[C:28]([O:35][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:29]([O:33][CH3:34])=[CH:30][CH:31]=2)[O:26][C:25](=[O:36])[CH:24]=1

Komponenten

3

Edukt 2

HCID 560317Disodium acetylideHCID 248495704-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one

Produkt 1

HCID 248498859-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)nonanoic acid

Versuchsvorschrift

The title compound was prepared from ethyl 9-bromononanoate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 42. 1H NMR (400 MHz, DMSO-d6): δ 9.50 (s, 1H), 8.81 (s, 2H), 7.93 (d, 1H), 7.19 (d, 1H), 4.63 (s, 1H), 3.97 (t, 2H), 3.91 (s, 3H), 2.17 (t, 2H), 1.66 (m, 2H), 1.52-1.38 (m, 4H), 1.34-1.22 (m, 6H); MS (ESI): 508.9.

Quellen und Nachweise

ORD-Eintrag
ord-e7134aad707d4a11b7a2632c60c4cdec
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745646B2

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