benzyl (S)-2-(morpholin-4-yl)propionate → (S)-2-Morpholin-4-yl-propionic acid

HRID 2068868

Reaktionsgleichung

Reaktionsgleichung von HRID 2068868
[N:1]1([C@@H:7]([CH3:18])[C:8]([O:10]CC2C=CC=CC=2)=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.[OH-].[Pd+2].[OH-].[C]>[N:1]1([C@@H:7]([CH3:18])[C:8]([OH:10])=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 13765076benzyl (S)-2-(morpholin-4-yl)propionate

Produkt 1

HCID 7059243(S)-2-Morpholin-4-yl-propionic acidAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178502593HCID 178502593, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Under an argon atmosphere, to a solution of benzyl (S)-2-(morpholin-4-yl)propionate (43 g, 172 mmol) in methanol (430 ml) was added 20% palladium hydroxide-carbon (4.3 g) at room temperature, and the mixture was stirred for 3 hr under a hydrogen atmosphere at normal pressure. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (25.4 g, 93%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-197a64d754284167a55ef50e8ed5f55a
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299070B2

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