Hydrochloric Acid → 2-(3-Bromo-5-methoxyphenyl)ethan-1-amine

Temperatur

80 °C

A borane-tetrahydrofuran complex (1 M, 73.6 mL) was added to a THF (36.8 mL) solution of Intermediate 3 at room temperature and the resulting mixture was stirred to reflux at 80° C. for 2 hours. Methanol (26 mL) and 1 N hydrochloric acid (26 mL) were added to the reaction mixture solution and the resulting mixture was stirred at room temperature for 1 hour. The resulting mixture was neutralized with 1 N aqueous sodium hydroxide solution followed by the addition of ethyl acetate (100 mL) to extract the reaction mixture, the organic layer was dried, and then the solvent was evaporated under reduced pressure to give the title compound (8.76 g).

1. stirringthe resulting mixture was stirred at room temperature for 1 hour
2. extractionto extract the reaction mixture
3. customthe organic layer was dried
4. customthe solvent was evaporated under reduced pressure

ORD-Eintrag

ord-311631ca28cd4032830eee9f6352f8bd

Quelldatensatz

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08299055B2