2-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

HRID 2069270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2069270
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:19])([F:18])[F:17])=[CH:6][C:5]=1[N+:20]([O-])=O>C(O)C.[Ni]>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:17])([F:18])[F:19])=[CH:6][C:5]=1[NH2:20]

Komponenten

4

Edukt 1

HCID 589645312-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

Produkt 1

HCID 589645242-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl esterAusbeute 84,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

300 mg of 2-nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester in 10 ml of dry ethanol are hydrogenated in presence of 60 mg of Raney nickel, After filtration of the catalyst the solution is evaporated to dryness yielding 233 mg of 2-amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 85-117° C. (decomp.).

Aufarbeitung

  1. filtrationAfter filtration of the catalyst the solution
  2. customis evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-991edd439a7e471bbb5257abb2cef030
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299085B2

Notizen zur Reaktion

Wird geladen…