HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Butoxybenzoic acid → N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Butoxybenzoic acid | HCID 72971 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Edukt | 4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide | HCID 69213108 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide | HCID 69208757 | — |
Reaktionsschritte
A mixture of 4-butoxybenzoic acid (156 mg) and DMF (10 ml) was mixed with TOTU (264 mg) and N,N-diisopropylethylamine (104 mg). After 10 minutes, 4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide (200 mg) was added. After one hour, the mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate, filtered and concentrated. The product with the molecular weight of 424.55 (C24H32N4O3) was obtained in this way; MS (ESI): 425 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08299104B2 |
| Quelldatensatz | uspto-grants-2012_10 |
| ORD ID | ord-a46ea26eb7344cf78e64e0e56da54b45 |
| Quellennotiz | uspto-grants-2012_10 |