Dimethylamine → 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

6-Fluoro-2H-isoquinolin-1-one (54 mg, 0.33 mmol) was deposited in a sealed tube with 5 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 3.5 hours. This was concentrated in vacuo and purified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes) to yield 6-Dimethylamino-2H-isoquinolin-1-one (39 mg, 0.21 mmol). MS (ESI) 189.1 (M+H)−.

Herkunft & Nachweise