Dimethylamine → 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one

HRID 2069743

Reaktionsgleichung

Reaktionsgleichung von HRID 2069743
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2.[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([CH3:15])[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 450908026-Fluoroisoquinolin-1(2H)-one

Produkt 1

HCID 574241426-(Dimethylamino)-1,2-dihydroisoquinolin-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

6-Fluoro-2H-isoquinolin-1-one (54 mg, 0.33 mmol) was deposited in a sealed tube with 5 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 3.5 hours. This was concentrated in vacuo and purified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes) to yield 6-Dimethylamino-2H-isoquinolin-1-one (39 mg, 0.21 mmol). MS (ESI) 189.1 (M+H)−.

Aufarbeitung

  1. concentrationThis was concentrated in vacuo
  2. custompurified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-45bdd3b449d544b8801d551331c06025
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299077B2

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