N-Methylpentylamine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methyl(pentyl)amino)pentyloxy)-2H-chromen-2-one

HRID 20710

Reaktionsgleichung

Reaktionsgleichung von HRID 20710
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[C:16]([O:35][CH3:36])=[CH:17][CH:18]=[C:19]2[C:24]=1[O:23][C:22](=[O:25])[CH:21]=[C:20]2[NH:26][C:27]1[C:32]([Cl:33])=[CH:31][N:30]=[CH:29][C:28]=1[Cl:34]>>[Cl:34][C:28]1[CH:29]=[N:30][CH:31]=[C:32]([Cl:33])[C:27]=1[NH:26][C:20]1[C:19]2[C:24](=[C:15]([O:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[C:16]([O:35][CH3:36])=[CH:17][CH:18]=2)[O:23][C:22](=[O:25])[CH:21]=1

Komponenten

3

Edukt 2

HCID 117479N-MethylpentylamineHCID 248495698-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one

Produkt 1

HCID 248493394-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methyl(pentyl)amino)pentyloxy)-2H-chromen-2-one

Versuchsvorschrift

The title compound was prepared from N-methylpentan-1-amine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.41 (br s, 1H), 8.57 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.23 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.61 (br, 4H), 2.39 (br s, 3H), 1.70 (m, 2H), 1.60 (m, 2H), 1.47 (m, 4H), 1.23 (m, 4H), 0.83 (t, 3H); MS (ESI): 522.1.

Quellen und Nachweise

ORD-Eintrag
ord-5a8960a0e1fa4ea0af7f1f7835b1cc32
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745646B2

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