Benzene → 2-[1-Chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

HRID 2071268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2071268
[Br:1][C:2]1[S:6][C:5]([N:7]=[C:8]=[O:9])=[N:4][CH:3]=1.C1C=CC=CC=1.[Cl:16][CH2:17][NH:18][CH2:19][CH:20]=[O:21]>C(O)C.O>[Cl:16][CH2:17][N:18]([CH2:19][CH:20]=[O:21])[C:8]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:9]

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 203927162-ChloromethylaminoacetaldehydeHCID 230622645-Bromothiazol-2-yl Isocyanate

Produkt 1

HCID 227684992-[1-Chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

5-Bromothiazol-2-yl isocyanate dimer (17.0 grams), benzene (70 ml) and the dimethyl acetal of 2-chloromethylaminoacetaldehyde (13.5 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is then stirred at room temperature for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent under reduced pressure, leaving an oil. This oil is dissolved in an ethanol-water mixture, and the solution is filtered. The filtrate is then stripped of solvents under vacuum to yield the desired product the dimethyl acetal of 2-[1-chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde.

Aufarbeitung

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered
  3. customleaving an oil
  4. filtrationthe solution is filtered

Quellen und Nachweise

ORD-Eintrag
ord-7efefc14b16a4ad79290f8dbfab67bd4
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04046768

Notizen zur Reaktion

Wird geladen…