4-Chlorophenyl Isocyanate → 1-(4-Chlorophenyl)-3-(1-methyl-2-piperidylidene)urea

HRID 2071524Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2071524
[NH:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH3:8].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[O:18])=[CH:12][CH:11]=1>C1C=CC=CC=1>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]([N:1]=[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][N:3]2[CH3:8])=[O:18])=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 76934-Chlorophenyl IsocyanateHCID 124490281-Methylpiperidin-2-imine

Produkt 1

HCID 536898361-(4-Chlorophenyl)-3-(1-methyl-2-piperidylidene)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

The hydrochloride salt of 2-imino-1-methylpiperidine (7.43 g.; 0.05 mole) is converted to the free base in benzene in the usual manner. After drying over K2CO3 and filtering, a benzene solution of 0.05 mole of p-chlorophenylisocyanate is added dropwise with stirring. After addition is complete, further stirring is continued for about 6 hours at room temperature. The benzene is evaporated in vacuo and the solid residue is recrystallized from methanol to give the product, 1-(4-chlorophenyl)-3-(1-methyl-2-piperidylidene)urea.

Aufarbeitung

  1. dry with materialAfter drying over K2CO3
  2. filtrationfiltering
  3. additionAfter addition
  4. stirringfurther stirring
  5. customThe benzene is evaporated in vacuo
  6. customthe solid residue is recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-162246a195174ef8aee1f169e9820df3
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04046909

Notizen zur Reaktion

Wird geladen…