1-Isopropylpiperazine → 1-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

HRID 2072286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072286
[NH:1]([C:8]1[C:9](=[O:20])[C:10](=[N:13][C:14]2[CH:19]=CC=CC=2)[C:11]=1[OH:12])[C:2]1[CH:7]=CC=CC=1.[CH:21]([N:24]1[CH2:29][CH2:28]NCC1)([CH3:23])[CH3:22]>>[OH-:12].[OH:12][C:11]1[C:10](=[N+:13]2[CH2:14][CH2:19][N:24]([CH:21]([CH3:22])[CH3:23])[CH2:29][CH2:28]2)[C:9](=[O:20])[C:8]=1[N:1]1[CH2:2][CH2:7][N:1]([CH:8]([CH3:9])[CH3:11])[CH2:2][CH2:7]1

Komponenten

3

Edukt 2

HCID 780131-IsopropylpiperazineHCID 109783293-Hydroxy-2-(phenylamino)-4-(phenylimino)-2-cyclobuten-1-one

Produkt 1

HCID 214077881-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

Versuchsvorschrift

A mixture of 4.0 grams of 2-anilino-3-hydroxy-4-(phenylimino)-2-cyclobuten-1-one and 3.9 grams of 1-isopropylpiperazine is heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes. The mixture is cooled and the resulting solid is comminuted, washed with anhydrous ethyl ether, dried and then recrystallized from water to give 1-[2-hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide inner salt melting at about 194.5°-196.5° C.

Aufarbeitung

  1. temperatureis heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes
  2. temperatureThe mixture is cooled
  3. customthe resulting solid is comminuted
  4. washwashed with anhydrous ethyl ether
  5. customdried
  6. customrecrystallized from water

Quellen und Nachweise

ORD-Eintrag
ord-c6989ee03f27499196d869232cfe657b
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04051136

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