Benzene → HCID 13239466, Verbindung

HRID 2072373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072373
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7](O)=[O:8].C1C=CC=CC=1.C(Cl)([Cl:24])=O.Cl>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7]([Cl:24])=[O:8]

Komponenten

6

Edukt 4

HCID 241BenzeneHCID 313Hydrochloric Acid2×HCID 6371Phosgene2×HCID 130607432-(3,5-Dichlorophenoxy)butanoic acid

Produkt 1

HCID 13239466HCID 13239466, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

71.8 g. (0.288 moles) of α-(3,5-dichlorophenoxy) butyric acid and 75 ml. of benzene are placed in a 500 ml. flask to which a dropping funnel with dry-ice condenser is attached. The slurry is stirred and the 0.2 ml. dimethyl formamide is added. The mixture is heated to 35° C. and 10 g. of phosgene is condensed into the mixture to initiate reaction. The start of the reaction is evidenced by HCl evolution and foaming. 26.0 g. more phosgene is added in 5 gm. increments. At the conclusion of the reaction (HCl evolution ceasing), the reaction mixture is evaporated leaving a residual liquid α-(3,5-dichlorophenoxy) butyryl chloride 77.6 g., ND20 = 1.5345

Aufarbeitung

  1. customflask to which a dropping funnel with dry-ice condenser is attached
  2. customcondensed into the mixture
  3. customreaction
  4. customthe reaction mixture is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-28cf9a306d3c41788870df9eaad6bd9f
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04051184

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