Diazomethane → Methyl 2-ethyl-thiazole-5-carboxylate
Reaktionsgleichung
[N+](=[CH2:3])=[N-].[CH2:4]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)[CH3:5]>C(Cl)Cl>[CH2:4]([C:6]1[S:7][C:8]([C:11]([O:13][CH3:3])=[O:12])=[CH:9][N:10]=1)[CH3:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of diazomethane in methylene chloride was added to a suspension of 10.45g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.
Aufarbeitung
- distillationthe methylene chloride was distilled The oily residue
- customwas chromatographed over silica
- washwas eluted with a 1:1 mixture of benzene-ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-994636cd792e4588bfe93b07f6dd5b5c
- Quelldatensatz
- uspto-grants-1977_09
- Patentnummer
- US04051249
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