Methyl iodide → 2-Bromo-4-(methylthio)aniline

HRID 2072590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072590
[Br:1][C:2]1[CH:8]=[C:7]([S:9][C:10]#N)[CH:6]=[CH:5][C:3]=1[NH2:4].[C-]#N.[Na+].CI>CO>[Br:1][C:2]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:3]=1[NH2:4]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 8929Sodium Cyanide2×HCID 38124212-Bromo-4-thiocyanatoaniline

Produkt 1

HCID 146018352-Bromo-4-(methylthio)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-4-thiocyanoaniline (11.5 g., 0.05 mole) and sodium cyanide (1.23 g., 0.025 mole) in methanol (100 ml.) is stirred at room temperature overnight. Sodium cyanide (0.025 mole) is then added and the reaction heated at reflux 2 hours and then cooled (0°-5° C.). Methyl iodide is added and stirring continued. Thin layer chromatography shows one product spot. Product is recovered by extraction with methylene chloride, 8.4 g.

Aufarbeitung

  1. temperaturethe reaction heated
  2. temperatureat reflux 2 hours
  3. temperaturecooled (0°-5° C.)
  4. customProduct is recovered by extraction with methylene chloride, 8.4 g

Quellen und Nachweise

ORD-Eintrag
ord-17ab256e09fa46588c1f0b202f82a60e
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04913728

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