tert-Butyl (4-chlorobutyl)carbamate → Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

HRID 2072820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072820
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14]([O:17][CH2:18][CH3:19])(=[O:16])[CH3:15].[OH2:20]>>[CH2:18]([O:17][C:14](=[O:16])[CH:15]([C:6]([O:5][CH2:1][CH3:2])=[O:20])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH3:19]

Komponenten

3

Edukt 2

HCID 19758183tert-Butyl (4-chlorobutyl)carbamateHCID 22728543Water ethylacetate

Produkt 1

HCID 53641101Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

Versuchsvorschrift

N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (2.5 g, 0.012 mol) is then gradually added to the resulting mixture at room temperature. The reaction mixture is stirred at room temperature for 2 hours and at the reflux temperature for 6 hours, and then poured into ethyl acetate/water (1/1, v/v) (100 ml). The organic phase is separated, washed several times with water, and dried over MgSO4.

Aufarbeitung

  1. customThe organic phase is separated
  2. washwashed several times with water
  3. dry with materialdried over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-0b0cc111c0634abcb66deed5e4ca8dc8
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04914226

Notizen zur Reaktion

Wird geladen…