3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid → 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid

Beteiligte Stoffe

Reaktionsschritte

Subsequently, 6.8 g of 3'-fluoro-4'-methoxybiphenyl-4-carboxylic acid was heated under reflux for 14 hours in 150 ml of 48% hydrobromic acid and 80 ml of dioxane. The volatile components were removed by evaporator, and the residue was washed several times with water to give 6.10 g (yield 95%) of the desired 3'-fluoro-4'-hydroxybiphenyl-4-carboxylic acid.

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