5-(Methylthio)-8-(3-(trifluoromethyl)phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one → 5-[(Phenylmethyl)amino)-8-[3-(trifluoromethyl)phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one

HRID 2073197

Reaktionsgleichung

Reaktionsgleichung von HRID 2073197
CS[C:3]1[N:13]2[C:14]3[N:9]([C:10]([C:15]4[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=4)=[CH:11][CH2:12]2)[N:8]=[CH:7][C:6]=3[C:5](=[O:25])[N:4]=1>C(N)C1C=CC=CC=1>[C:15]1([CH2:10][NH:9][C:3]2[N:13]3[C:14]4[N:9]([C:10]([C:15]5[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:16]=5)=[CH:11][CH2:12]3)[N:8]=[CH:7][C:6]=4[C:5](=[O:25])[N:4]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

3

Edukt 1

HCID 98853995-(Methylthio)-8-(3-(trifluoromethyl)phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one

Produkt 1

HCID 212239495-[(Phenylmethyl)amino)-8-[3-(trifluoromethyl)phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7504BenzylamineLösungsmittel

Versuchsvorschrift

A 200 mg amount of 5-(methylthio)-8-[3-trifluoromethyl)phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one (prepared as described in Example 9) was suspended in 10.0 ml of benzylamine. The reaction mixture was cooled to room temperature and filtered. The solid on the filter was washed with ether and air dried to give 189 mg of the product of the example as a white solid, m.p. 220°-224° C.

Aufarbeitung

  1. filtrationfiltered
  2. washThe solid on the filter was washed with ether and air
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-33e2e1aa970946798fd05a4c0061b597
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04916137

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