1-(2-Pyridyl)piperazine → HCID 59763826, Verbindung
Reaktionsgleichung
[CH2:1]([N:3]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[N:5]=[C:4]1[C:11]([O:13]CC)=O)[CH3:2].[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH2:1]([N:3]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[N:5]=[C:4]1[C:11]([N:25]1[CH2:26][CH2:27][N:22]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)[CH2:23][CH2:24]1)=[O:13])[CH3:2]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A mixture of 1.23 g (5.06 mmol) of ethyl 1-ethyl-4-nitro-1H-imidazole-2-carboxylate (prepared in analogy to Example 10A) and 2.48 g (15.2 mmol) of N-(pyridin-2-yl)piperazine is stirred at 100° C. overnight. For the work-up, the crude mixture obtained is purified by preparative HPLC. 0.724 g (43% of theory) of product are obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-7b820546f2d545e2821f6791b2f5d07c
- Quelldatensatz
- uspto-grants-2011_04
- Patentnummer
- US07919489B2
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