Methyl iodide → HCID 178483384, Verbindung

HRID 2075428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2075428
[CH3:1][N:2]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)[CH3:3].[CH3:14][I:15]>C(OCC)(=O)C>[I-:15].[NH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([CH2:4][N+:2]([CH3:14])([CH3:1])[CH3:3])=[N:6]1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 178483331(1H-Indazol-3-yl)-N,N-dimethylmethanamine

Produkt 1

HCID 178483384HCID 178483384, VerbindungAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-Dimethylaminomethyl-1H-indazole (25.6 g, 146 mmol) obtained in Step 2 was dissolved in ethyl acetate (350 mL), and the solution was added with methyl iodide (33.3 mL, 535 mmol), followed by stirring at room temperature overnight. The resulting precipitates were collected by filtration to obtain (1H-indazol-3-ylmethyl)trimethylammonium iodide (45.0 g, 97%).

Aufarbeitung

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5bab7faaed084fa6b6a4e1182aafa751
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07919517B2

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