6-[1-Dimethylamino-methylidene]-2-methyl-2-phenylcyclohexanone → [3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-(8-methyl-8-phenyl-5,6,7,8-tetrahydro-quinazolin-2-yl)-amine
Reaktionsgleichung
CN(C)[CH:3]=[C:4]1[C:9](=O)[C:8]([CH3:17])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6][CH2:5]1.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[F:27][C:28]1[CH:29]=[C:30]([NH:40][C:41]([NH2:43])=[NH:42])[CH:31]=[CH:32][C:33]=1[N:34]1[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]1>>[F:27][C:28]1[CH:29]=[C:30]([NH:40][C:41]2[N:43]=[CH:3][C:4]3[CH2:5][CH2:6][CH2:7][C:8]([CH3:17])([C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:9]=3[N:42]=2)[CH:31]=[CH:32][C:33]=1[N:34]1[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 6-[1-dimethylamino-methylidene]-2-methyl-2-phenylcyclohexanone (117 mg, 0.48 mmol) and N-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (130 mg, 0.36 mmol) using in analogous manner the procedure described in example 48b). Obtained as a pale-yellow solid (44 mg, 30%). MS ISP (m/e): 414.4 [(M+H)+]. mp 157-158° C.