Hydrochloric Acid → 7-(5-Ethoxypyridin-3-yl)-1,7-diazaspiro[4.4]nonane

HRID 2076405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2076405
C([N:8]1[C:12]2([CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[N:19][CH:20]=[C:21]([O:23][CH2:24][CH3:25])[CH:22]=3)[CH2:13]2)[CH2:11][CH2:10][CH2:9]1)C1C=CC=CC=1.Cl.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:24]([O:23][C:21]1[CH:22]=[C:17]([N:14]2[CH2:15][CH2:16][C:12]3([NH:8][CH2:9][CH2:10][CH2:11]3)[CH2:13]2)[CH:18]=[N:19][CH:20]=1)[CH3:25]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 222912451-Benzyl-7-(5-ethoxypyridin-3-yl)-1,7-diazaspiro[4.4]nonaneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 222912427-(5-Ethoxypyridin-3-yl)-1,7-diazaspiro[4.4]nonaneAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 1-benzyl-7-(5-ethoxy-3-pyridyl)-1,7-diazaspiro[4.4]nonane (540 mg, 1.6 mmol) in ethanol (25 mL) in a pressure bottle was added concentrated HCl (1 mL) and Pearlman's catalyst (Pd(OH)2, 20% on carbon, 50 mg). The solution was shaken under 50 psi of hydrogen gas for 8 h. The catalyst was removed by filtration through Celite, and the filter cake was washed with ethanol (20 mL). The solvent was removed by rotary evaporation, and the residue was basified with saturated aqueous sodium bicarbonate to pH 8-9. Solid sodium chloride (2 g) was added, and the mixture was extracted with chloroform (4×20 mL). The combined chloroform extracts were dried (Na2SO4), filtered and concentrated by rotary evaporation to afford 360.7 mg of the desired compound as a light brown viscous liquid (91.1%).

Aufarbeitung

  1. customThe catalyst was removed by filtration through Celite
  2. washthe filter cake was washed with ethanol (20 mL)
  3. customThe solvent was removed by rotary evaporation
  4. additionSolid sodium chloride (2 g) was added
  5. extractionthe mixture was extracted with chloroform (4×20 mL)
  6. dry with materialThe combined chloroform extracts were dried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated by rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-4a461bbbc2eb4281b1f4755821725d53
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923559B2

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