Hydrochloric Acid → 6-Bromo-N-methylbenzo[d]thiazol-2-amine
Reaktionsgleichung
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7](Cl)[S:8][C:4]=2[CH:3]=1.C(O)C.[CH3:15][NH2:16].Cl>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH:16][CH3:15])[S:8][C:4]=2[CH:3]=1Komponenten
Versuchsvorschrift
6-bromo-2-chlorobenzo[d]thiazole (1.100 g, 4.4 mmol) and ethanol (20 ml, 343 mmol) was added to a microwave vial equipped with a stirbar. Then methylamine solution, 40% (2.3 ml, 66 mmol) was added to the mixture with stirring. Then HCl (0.34 ml, 11 mmol) was added to the mixture. The vial was capped then placed into the CEM Voyager Microwave (large-scale unit) for 15 minutes at 100° C., while 60 watts of energy was supplied via Powermax® (Simultaneous heating while cooling technology). The progress of the reaction was monitored by LC/MS, which showed mostly desired material in the mixture. The mixture was transferred to a round-bottom flask, then made the mixture basic with sat. Na2HCO3. The precipitate was collected by filtration and washed with Hexanes. The solid was allowed dry in a reduced pressure oven overnight. This gave 6-bromo-N-methylbenzo[d]thiazol-2-amine (0.850 g, 79% yield) as a tan crystalline solid. MS (ESI pos. ion) m/z: 244 (MH+). Calc'd exact mass for C8H7BrN2S: 243. 1H NMR (400 MHz, DMSO-d6): 2.93 (d, J=4.52 Hz, 3H), 7.33 (q, J=8.53 Hz, 2H), 7.90 (s, 1H), 8.06 (d, J=4.52 Hz, 1H).
Aufarbeitung
- customvial equipped with a stirbar
- customThe vial was capped
- temperaturewas supplied via Powermax® (Simultaneous heating while cooling technology)
- customThe mixture was transferred to a round-bottom flask
- filtrationThe precipitate was collected by filtration
- washwashed with Hexanes
- customThe solid was allowed dry in a reduced pressure oven overnight
Quellen und Nachweise
- ORD-Eintrag
- ord-97b247416ac54bdf9bd1791afaf70de1
- Quelldatensatz
- uspto-grants-2011_04
- Patentnummer
- US07928140B2
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