Phthalic Anhydride → (2-Benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylsulfanyl)-acetic acid ethyl ester
Reaktionsgleichung
[C:1]1(=O)OC(=O)C2=CC=CC=[C:2]12.[CH3:12][O:13][C:14](=[O:33])[CH2:15][S:16][CH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])[N:18]1[CH2:27][C:28]1S[CH:30]=[CH:31][CH:32]=1.[CH2:34](N)C1C=CC=CC=1>>[CH2:12]([O:13][C:14](=[O:33])[CH2:15][S:16][CH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])[N:18]1[CH2:27][C:28]1[CH:2]=[CH:1][CH:30]=[CH:31][CH:32]=1)[CH3:34]Komponenten
4
Versuchsvorschrift
Compound 17 was prepared using the synthetic sequence in a manner analogous to the method described for the conversion of commercially available phthalic anhydride to compound 13 using benzylamine instead of thiophene-2-methylamine in the first step.